An abstract to be presented during this afternoon’s “Embolization: Musculoskeletal” scientific session outlines an IR treatment that could delay or defer knee surgery for patients with osteoarthritis.
Sandeep Bagla, MD, director of interventional radiology at the Vascular Institute of Virginia, will present “Geniculate artery embolization (GAE) for osteoarthritis (OA)-related knee pain: Interim results from a multicenter U.S. trial” as part of the session that takes place from 3–4:30 p.m. in Room 410.
GAE, a minimally invasive, image-guided treatment that blocks key arteries in the knee to reduce inflammation and pain, resulted in a majority of study participants achieving significant pain reduction and improvements in range of motion, avoiding more invasive measures, according to the abstract.
“A majority of our patients with osteoarthritis of the knee saw significant pain reduction, not only just a few days after the procedure, but a month after as well, making this an accessible treatment for patients looking to avoid surgery and improve their quality of life,” said Dr. Bagla, lead author of the study. “We are very encouraged by the results and the implications for the millions suffering from this common, yet debilitating, condition.”
This prospective, multicenter clinical trial evaluated 13 patients with severe OA pain. Each patient’s pain and disability were measured along two scales, with evaluations before and after the treatment. The treatment was successfully completed in all 13 patients, with no adverse events. One month later, researchers followed the progress of eight patients and found that GAE significantly decreased pain (-58 mm on the Visual Analog Scale), reduced stiffness and increased physical function (-36.3 on the Western Ontario and McMaster University Osteoarthritis Index). Together the scales represent an 80 percent improvement in function compared with pre-procedure conditions.
This study builds on the growing international research around GAE and OA. While preliminary data shows that the treatment does work and is feasible, it has only been used in a clinical trial setting. The study has completed enrollment of 20 patients and final results are expected in summer 2018. A second randomized controlled clinical trial began in February 2018 and will provide further data on what types of patients are the best candidates for this treatment and how it could move toward clinical practice.
As an outpatient treatment, GAE does not require open surgery or physical therapy and takes 45–90 minutes to perform. Interventional radiologists insert catheters through a pinhole-sized incision, blocking the very small arteries or capillaries within the lining of the knee, reducing the inflammation caused by OA.
“This procedure could have a significant impact in the treatment of osteoarthritis pain as a whole,” Dr. Bagla said. “The current mainstay of treatment in patients who have arthritis are pain medications, which come with significant side effects and risks and have been associated with a dangerous epidemic in the United States. But GAE provides another option for patients struggling with pain and may even allow patients to avoid the lengthy recovery of knee surgery and reduce or stop their pain medications.”
The abstract can be found at sirmeeting.org.